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Genesis of WGM Bio-sensor  

  1. Excitation of resonances of microspheres on an optical fiber
    A. Serpengüzel, S. Arnold and G. Griffel
    Opt. Lett 20, 654 (1995)

     

Popular Science Articles  

  1. Microspheres, Photonic Atoms and the Physics of Nothing
    S. Arnold
    American Scientist 89, 414-421 (2001)
     
  2. Microesferas, átomos fotónicos y la física de la nada (in Spanish)
    S. Arnold
    INVESTIGACIÓN Y CIENCIA 76-83, (febrero 2003)

     
  3. Magic of glass sphere photonic sensors (in Japanese)
    I. Teraoka
    Nikkei Science 33, No. 6, 1 (2003)

     
  4. Whispering-gallery-mode biosensing: label-free detection down to single molecules
    F. Vollmer & S. Arnold
    Nature Methods, 5, 591 -596 (2008).
     
  5. Measuring the light infinitesmal
    S. Arnold
    The SPEX speaker, 22, 1-7 (1977)
     

Refereed Publications

  1. Whispering gallery mode coulometry of the nanoparticle-microcavity interaction in aqueous solution
    J.R. Lopez, E. Treasurer, K.M. Snyder, D. Keng, and S. Arnold
    Appl. Phys. Lett., 2018, 112, 051109
     
  2. Whispering gallery mode single nano-particle detection and sizing: the validity of the dipole approximation
    M.R. Foreman, D. Keng, E. Treasurer, J.R. Lopez, and S. Arnold
    Optics Lett., 2017, 42, 963-966.
     
  3. Hybrid whispering gallery mode/plasmonic chain ring resonators for biosensing
    E. Arbabi, SM. Kamali, S. Arnold, and LL. Goddard
    Appl. Phys. Lett., 2014, 105, 231107.
     
  4. Mode broadening induced by nanoparticles in an optical whispering-gallery microcavity
    Y. Hu, L. Shao, S. Arnold, YC. Liu, CY. Ma, and YF. Xiao
    Phys Rev. A, 2014, 90, 043847.
     
  5. Whispering Gallery Micro-Global Positioning System For Nanoparticle Sizing In Real Time
    D. Keng, X. Tan and S. Arnold
    Appl. Phys. Lett., 2014, 105, 071105.
     
  6. Label-Free Detection of Single Protein Using a Nanoplasmonic-Photonic Hybrid Microcavity
    V.R. Dantham, S. Holler, C. Barbre, D. Keng, V. Kolchenko, and S. Arnold
    Nano Lett., 2013, 13 (7), pp 3347–3351.
     
  7. Polynomial Smoothing of Time Series With Additive Step Discontinuities
    I.W. Selesnick, S. Arnold, and V.R. Dantham
    IEEE Transactions on Signal Processing, 60, NO. 12, (2012).
     
  8. Periodic plasmonic enhancing epitopes on a whispering gallery mode biosensor
    S. Arnold, V.R. Dantham, C. Barbre, B.A. Garetz, X.Fan
    Optics Express, 20, 26147 (2012).
     
  9. Taking whispering gallery-mode single virus detection and sizing to the limit
    V. R. Dantham, S. Holler, V. Kolchenko, Z. Wan, and S. Arnold
    Applied Physics Letters,101,043704 (2012).
     
  10. Pasmonic Enhancement of a Whispering-Gallery-Mode Biosensor for Single Nanoparticle detection
    S. I. Shopova, R. Rajmangal, S. Holler, and S. Arnold
    Applied Physics Letters, 98, 243104 (2011).

     
  11. Microesferas, átomos fotónicos y la física de la nada (in Spanish)
    S. Arnold
    INVESTIGACIÓN Y CIENCIA 76-83, (febrero 2003)

     
  12. Microspheres, Photonic Atoms and the Physics of Nothing
    S. Arnold
    American Scientist 89, 414-421 (2001)
     

  13. Ultra-sensitive Nanoparticle Detection using a Portable Whispering Gallery Mode Biosensor driven by a PPLN doubled DFB laser
    S. I. Shopova, R. Rajmangal, Y. Nishida, S. Arnold
    Review of Scientific Instruments 81, 103110 (2010).


  14. Bioinspired optofluidic FRET lasers via DNA scaffolds
    Yuze Sun, Siyka I. Shopova, Chung-Shieh Wu, Stephen Arnold, and Xudong Fan
    PNAS, 107, 16039-16042 (2010).


  15. Whispering gallery mode bio-sensor for label-free detection of single molecules: thermo-optic vs. reactive mechanism
    S. Arnold, S. I. Shopova, S. Holler
    Optics Expess 18, 281-287 (2010).


  16. Resonance shifts of counterpropagating whispering-gallery modes: degenerate perturbation theory and application to resonator sensors with axial symmetry nanoparticle detection in biosensing
    I. Teraoka, and S. Arnold
    J. Opt. Soc. Am. B, Vol. 26 No. 7, 1321 -1329 (2009).


  17. Whispering gallery mode carousel – a photonic mechanism for enhanced nanoparticle detection in biosensing
    S. Arnold, D. Keng, S. I. Shopova, S. Holler, W. Zurawsky, and F. Vollmer
    Opt. Express, 17, 6230-6238 (2009).


  18. Single virus detection from the reactive shift of a whispering-gallery mode
    F. Vollmer, S. Arnold, and D. Keng
    PNAS, 105, 20701-20704 (2008).


  19. Variational principle in whispering gallery mode sensor responses
    I. Teraoka & S. Arnold
    J. Opt. Soc. Am. B, 25, 1038 -1045 (2008).


  20. Whispering-gallery-mode biosensing: label-free detection down to single molecules
    F. Vollmer & S. Arnold
    Nature Methods, 5, 591 -596 (2008).


  21. MicroParticle photophysics illuminates viral bio-sensing
    S. Arnold, R. Ramjit, D. Keng, V. Kolchenko and I. Teraoka
    FARADAY DISCUSSIONS 137, 65-83 (2008), DOI: 10.1039/b702920a.


  22. Estimation of surface density of molecules adsorbed on a whispering gallery mode resonator: Utility of isotropic polarizability
    I. Teraoka, S. Arnold
    J. of Appl. Phys. 102, 076109 (2007)


  23. High-Q microsphere biosensor - analysis for adsorption of rodlike bacteria
    H. Ren, F. Vollmer,, S. Arnold and A. Libchaber
    Opt. Express 15, 17410 (2007)


  24. Resonance fluctuations of a whispering gallery mode biosensor by
    particles undergoing Brownian motion
    D. Keng, S. R. McAnanama, I. Teraoka, and S. Arnold
    Appl. Phys. Lett. 91, 103902 (2007)


  25. Detection of Protein Orientation on the Silica Microsphere Surface Using
    Transverse Electric/Transverse Magnetic Whispering Gallery Modes
    M. Noto, D. Keng, I. Teraoka, and S. Arnold
    Bio. Phys. J., 92, 4466-4472 (2007)


  26. Coupled whispering gallery modes in a multilayer-coated microsphere
    I. Teraoka, and S. Arnold
    Opt. Lett. 32, No. 9, 1147 (2007)


  27. Whispering-gallery modes in a microsphere coated with a high-refractive index layer:
    polarization-dependent sensitivity enhancement of the resonance-shift sensor and TE–TM resonance matching
    I. Teraoka, and S. Arnold
    J. Opt. Soc. Am. B, 24, No. 3, 653 (2007)


  28. Dielectric property of particles at interface in random sequential adsorption and its application to whispering gallery mode resonance-shift sensors
    I. Teraoka, and S. Arnold
    J. of Appl. Phys. 101, 023505 (2007)


  29. Enhancing sensitivity of a whispering gallery mode biosensor by subwavelength confinement
    O. Gaathon, J. Culic-Viskota, M. Mihnev, I. Teraoka, and S. Arnold
    Appl. Phys. Lett. 89, 223901 (2006)


  30. Temperature measurements using a microoptical sensor based on whispering gallery modes
    G. Guan, S. Arnold and M. V. Otugen
    AIAA JOURNAL, Vol. 44, 2385 (2006)


  31. Enhancing the sensitivity of a whispering-gallery mode microsphere sensor by a high-refractive-index surface layer
    I. Teraoka and S. Arnold
    J. Opt. Soc. Am.B, 23, 1434 (2006)


  32. Theory of resonance shifts in TE and TM whispering gallery modes by nonradial perturbations for sensing applications
    I. Teraoka and S. Arnold
    J. Opt. Soc. Am.B, 23, 1381 (2006)


  33. Molecular weight dependence of a whispering gallery mode biosensor
    M. Noto, M. Khoshsima, D. Keng, I. Teraoka, V. Kolchenko, and S. Arnold
    Appl. Phys. Lett. 87, 223901 (2005)


  34. Nanolayer characterization through wavelength multiplexing
    of a microsphere resonator
    M. Noto, F. Vollmer, D. Keng, I. Teraoka, S. Arnold
    Opt. Lett. 30, No. 5 (2005)
    Read the MRS bulletin, “ Wavelength multiplexing of microsphere resonators used to characterize nanolayers.”


  35. Polarized transmission spectra of the fiber-microsphere system
    G. Guan, F. Vollmer
    Appl. Phys. Lett. 86, 121115 (2005)


  36. Strong dc Electric Field Applied to Supersaturated Aqueous
    Glycine Solution Induces Nucleation of the γ Polymorph
    J. Aber, S. Arnold, B. Garetz
    Physical Review Letters 94,145503 (2005)

     
  37. Multiplexed DNA Quantification by Spectroscopic Shift of Two Microsphere Cavities
    F. Vollmer, S. Arnold, D. Braun, I. Teraoka, A. Libchaber
    Bio. Phys. J., 85, 1974-1979, 2003
     Read the news article from Biophotonics Internatonal, “Silica microspheres enable sensitive DNA detection.”
    38.  
  38. Perturbation Approach to Resonance Shift of Whispering Gallery Modes
    in Dielectric Microspheres as a Probe of a Surrounding Medium
    I. Teraoka, S. Arnold, F. Vollmer
    J. Opt. Soc. B, in press, 2003

     
  39. Shift of Whispering Gallery Modes in Microspheres by Protein Adsorption
    S. Arnold, M. Khoshsima, I. Teraoka, S. Holler, F. Vollmer
    Opt. Lett. 28, 272-274 (2003)
     
  40. Protein Detection by Optical Shift of a Resonant Microcavity
    F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, S. Arnold
    Appl.Phys.Lett. 80, 4057(2002)
    Research highlight in Nature, “Whisper detection of proteins.”

     
  41. Excitation of resonances of microspheres on an optical fiber
    A. Serpengüzel, S. Arnold and G. Griffel
    Opt. Lett 20, 654 (1995)

     

Downloadable Thesis Mentored by MP3L Staff

  1. Inelastic Scattering from Microparticles:Fluorescence Microscopy and Spectroscopy of Oriented Molecules within a Levitated Microdroplet
    Noel Lee Goddard (MS Chemistry)
    May 1998
     
  2. Purturbation of whispering gallery modes in microspheres by protein adsorption:
    Theory and Experiment
    Maziar Khoshsima (Ph.D. Physics)
    Jan. 2004
     
  3. Resonant Detection of Nano to Microscopic Objects Using Whispering Gallery Modes
    Frank Vollmer (Ph.D. BioPhysics)
    May 2004
     
  4. Surface Interaction, Polarization and Molecular Weight Effects for a Whispering Gallery Mode Sensor
    Mayumi Noto (Ph.D. Material Science)
    May 2005

     
  5. Breaking the Limit for BioSensing:
    Sensitivity Enhancement of Resonant Cavity due to SubWavelength Confinement by Heterogeneous Dielectric Layering
    Ophir Gaathon (BS Electrical Engineering)
    May 2006

     
  6. Nano Sensing Using Nano Optics
    Momchil Mihnev (BS Electrical Engineering)
    May 2006

     
  7. To Be Uploaded
    NA
    May 2006

     
  8. Whispering Gallery Mode BioParticle Sensing and Transport
    David Keng (Ph.D. BioMedical Engineering)
    May 2009

     
  9. Polymer Microsphere Attachment to a Silicon Telecom Fiber for Whispering Gallery Mode Biosensing
    Ying Chen (MS Chemistry)
    Jan. 2012

     
  10. Toward a Label-Free Single Molecule, Functionalized, Size/Mass Spectrometer For Bio-Complex Analysis With Microcavities
    Eshan Treasurer (MS Chemical Engineering)
    Sept. 2015

     
  11. To Be Uploaded
    Xiaotian Tan (BS Electrical Engineering)
    Sept. 2015

     

Book Chapters

  1. Mechanical Probes to Nanoparticle-Microcavity Interaction and Charge
    S. Arnold, J.R. Lopez, E. Treasurer, K.M. Snyder, D. Keng
    Quantum Nano-Photonics. NATO 2017. NATO Science for Peace and Security Series B: Physics and Biophysics
    (Springer, Dordrecht, 2018)
     
  2. Whispering Gallery Mode Biosensor: Fulfilling the Promise of Single Virus Detection without Labels ultra-sensitive specific sensing of bio-molecules
    S. Arnold and S.I. Shopova
    Biophotonics: Spectroscopy, Imaging, Sensing, and Manipulation,
    (Springer, Netherlands, 2011)

     
  3. Spectrosocpy of photonic atoms: a means for
    ultra-sensitive specific sensing of bio-molecules
    S. Arnold and O. Gaathon
    in Advances in Spectroscopy for Lasers and Sensing,
    (Springer, Netherlands, 2006)

     
  4. Consequences of extreme photon confinement in micro-cavities:
    Ultra-sensitive detection of perturbations
    by bio-moleculesa in Frontiers of Optical Spectroscopy:
    Investigating Extreme Physical Conditions with Advanced Optical Techniques
    S. Arnold, M. Noto, and F. Vollmer
    Eds. Baldassare DiBartolo
    (Kluwer Academic Publichers, 2005)pp. 465-489

In Addition there have been more than 40 papers in Proceedings, and more than 100 abstracts.