MicroParticle photophysics illuminates viral bio-sensing
S. Arnold, R. Ramjit, D. Keng, V. Kolchenko and I. Teraoka
FARADAY DISCUSSIONS 137, 65-83 (2008), DOI: 10.1039/b702920a.
The authors present an approach for specific and rapid
unlabeled detection of virus by using a
microsphere based whispering gallery mode sensor that transduces the interaction of a whole virus
with an anchored antibody. They show theoretically that this sensor can detect a single virion
below the mass of HIV. A micro-fluidic device is presented that enables the discrimination
between viruses of similar size and shape.